Optimizing Second-generation Drug-eluting Stents

Optimizing Second-generation Drug-eluting Stents – Spray Coater – Cheersonic

In order to solve the problem of late thrombosis risk, after 2006, the second generation of drug-eluting stents embarked on the road of comprehensive optimization, mainly from the three aspects of stent platform, drug and coating.

Optimization

1. Optimization of the bracket platform:

Nickel-titanium alloy or cobalt-chromium alloy and other alternatives to stainless steel have improved stent metal performance, higher alloy density, thinner stent beam, less impact on blood flow, and easier endothelialization; at the same time, the radial support force and fatigue resistance of the stent are guaranteed. .

2. Drug optimization:

Rapamycin and its derivatives replace paclitaxel, and rapamycin and its derivatives are safer, mainly by inhibiting cell proliferation and inhibiting the occurrence of restenosis. Paclitaxel is an anticancer drug that kills abnormally dividing cells by inhibiting cell mitosis and triggering apoptosis.

3. Coating optimization:

Second-generation drug-eluting stents either use a biodegradable coating to shorten their in-vivo duration, or improve the coating’s biocompatibility to make them safe for long periods of time in the body.

Comparing the incidence of thrombotic events between different stents, the results show that compared with bare stents or first-generation drug-eluting stents, second-generation drug-eluting stents have lower rates of restenosis; lower incidence of thrombosis; lower mortality; very late thrombosis Rates (> 1 year) did not increase significantly.

The ultrasonic drug-eluting stent spray system can be used to prepare a polymer coating to prevent restenosis on the surface of implantable drug-eluting stents. Compared to conventional two-fluid nozzles, the ultrasonic nozzles can spray a more uniform drug coating that completely covers the stent without orange peel. The soft, atomized spray adheres well to the surface, and the morphological characteristics of the coating can be tuned by modifying the process parameters. In addition, the stent coating obtained by ultrasonic spray technique is thinner than dip coating. Ultrasonic spraying technology can precisely control the amount of drug sprayed on the stent, so that the spraying control is more precise.

Source: Medtec China

Cheersonic is the leading developer and manufacturer of ultrasonic coating systems for applying precise, thin film coatings to protect, strengthen or smooth surfaces on parts and components for the microelectronics/electronics, alternative energy, medical and industrial markets, including specialized glass applications in construction and automotive.